Promethazine is surely an H1 receptor blocking agent. In combination with its antihistaminic motion, it provides clinically helpful sedative and antiemetic effects.
Promethazine HCl Oral Answer is contraindicated in comatose states, and in people today known for being hypersensitive or to possess experienced an idiosyncratic response to promethazine or to other phenothiazines.
If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the affected person off from the opioid to permit adrenal purpose to Get better and keep on corticosteroid therapy until adrenal functionality recovers. Other opioids may be experimented with as some scenarios claimed use of a different opioid without having recurrence of adrenal insufficiency. The information offered doesn't identify any certain opioids as being much more likely to be connected to adrenal insufficiency.
Lifestyle-threatening respiratory challenges (respiratory depression). Promethazine Hydrochloride and Codeine Phosphate Oral Answer might cause respiration issues (respiratory depression) which will come about at any time in the course of cure and can cause Dying. Your chance of breathing issues is greatest if you initially get started taking Promethazine Hydrochloride and Codeine Phosphate Oral Remedy, are getting other medicines that may cause respiration troubles, have selected lung issues, are aged or have specified other medical problems.
e., a number of copies with the gene for cytochrome P450 isoenzyme 2D6 or large morphine concentrations). Children with sleep apnea may be specifically sensitive to your respiratory depressant results of codeine.
Promethazine Carcinogenicity studies were being carried out with promethazine hydrochloride. Two-calendar year experiments in F344/N rats and B6C3F1 mice were being conducted to evaluate the carcinogenic probable of promethazine hydrochloride. No evidence of tumorigenicity was observed in male and feminine rats at promethazine hydrochloride oral doses nearly 33 mg/kg/day for 5 days/week (approximately reminiscent of read more 10 occasions the MRHD over a mg/m2 basis).
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Promethazine HCl and Codeine Phosphate Oral Remedy is indicated for that temporary reduction of coughs and upper respiratory symptoms connected with allergy or the popular chilly in individuals 18 several years of age and older.
g., amiodarone, quinidine) could lead to a rise in codeine plasma concentrations in addition to a minimize in active metabolite morphine plasma concentration which could bring about an analgesic efficacy reduction or signs of opioid withdrawal.
Promethazine HCl occurs for a white to faint yellow, virtually odorless, crystalline powder which slowly but surely oxidizes and turns blue on prolonged exposure to air. It can be freely soluble in water and soluble in Liquor.
The average effective dose of Promethazine for your Energetic therapy of nausea and vomiting in small children or adults is 25 mg.
Usually, dose choice for an aged patient really should be cautious, normally beginning in the small conclude in the dosing selection, reflecting the greater frequency of diminished hepatic, renal or cardiac functionality, and of concomitant condition or other drug therapy.
In animal replica studies, codeine administered through the oral route to pregnant rats in the course of the duration of organogenesis amplified resorptions and reduced fetal weights at a dose around 25 instances the utmost advised human dose (MRHD) while in the presence of maternal toxicity (see Information).
Bone-marrow complications and blood mobile creation. Promethazine HCl Oral Option really should not be Employed in people with bone-marrow problems or utilized with other medicines that have an impact on the bone marrow's production of blood cells.